Potential risk genotypes associated with symptoms of pesticide poisoning based on polymorphisms in the XRCC1 ( <i>rs25487</i> and <i>rs1799782</i> ), SOD2 ( <i>rs4880</i> ), PON1 ( <i>rs662</i> ) and GSTP1 ( <i>rs1695</i> ) genes, in farmers in the C

The variants in the genes involved in the defense mechanisms against pesticide poisoning could be the cause to develop symptoms of poisoning with these substances. In this work, we analyzed polymorphisms in genes that defend against pesticide poisoning in 112 farmers from the Cienega region of Jalisco. We genotyped the variants <i>rs25487</i> and <i>rs1799782</i> of the <i>XRCC1</i> gene, <i>rs28360135</i> of the <i>XRCC4</i> gene, <i>rs4880</i> of the <i>SOD2</i> gene and <i>rs662</i> and <i>rs1695</i> of the PON1 and <i>GSTP1</i> genes, respectively. For <i>rs25487</i> (AA vs AG; <i>p</i> = 0.045), significance was found with heart palpitations, <i>rs1799782</i> with salivation (CC vs CT; <i>p</i> = 0.038), <i>rs4880</i> with sweating (TT+TC vs CC; <i>p</i> = 0.026; TC vs CC; <i>p</i> = 0.034) and <i>rs662</i> with cough (AA vs AG+GG; <i>p</i> = 0.001; AA vs AG; <i>p</i> = 0.006; AA vs GG; <i>p</i> = 0.027) and salivation (AG vs GG; <i>p</i> = 0.037). Furthermore, the variant <i>rs1799782</i> found significance with carbamates (<i>p</i> = 0.049) and pyrethroids (<i>p</i> = 0.015), as well as the TT versus TC+CC (<i>p</i> = 0.043) and TT versus TC (<i>p</i> = 0.034) genotypes of <i>rs4880</i> with carbamates. Finally, AA+AG versus GG (<i>p</i> = 0.039) and AG versus GG (<i>p</i> = 0.025) genotypes of the <i>rs1695</i> polymorphism were also significant with carbamates. Except for the <i>XRCC4 rs28360135</i> and <i>GSTP1 rs1695</i> variants, the rest of the polymorphisms showed significance with symptoms of acute poisoning. The presence of <i>XRCC1</i> (<i>rs1799782</i>), <i>SOD2</i> (<i>rs4880</i>) and <i>GSTP1</i> (<i>rs1695</i>) variants may be risk factors for carbamate and pyrethroid poisoning.