Bioinformatics Datamining Helps Elucidate Molecular Mechanisms of Deregulated Genes in Gynecological Cancers

Cancer has emerged as a major cause of mortality in recent years. Gynecological cancer cases are rising and are imposing a burden on the socio-economic fronts. Diagnosis and treatment of cancer is a challenging task involving the use of both long work hours and money. Identification of therapeutic targets and biomarkers can aid in both diagnosis and therapy. Datamining of Public gene and protein databases was performed to analyze the expression of deregulated genes identified in a pilot study involving comparison of cervical tumors and adjoining non-cancerous tissues. The expressions of HES4, PMVK, SRM, Dermatopontin, GSTM5 and BCL2L15 the dysregulated genes and their encoded proteins were analyzed in breast, cervical and endometrial cancers using Human protein atlas, Uni prot KB, STRING and GENT2 Databases. The study reinforced the results obtained in the pilot study. HES 4, PMVK and SRM genes were found to be upregulated and Dermatopontin, BCL2L15 and GSTM5 were found to be downregulated in all the gynecological cancers. These can serve as novel biomarkers and therapeutic targets. The study has limitations in that the findings have to be validated using wet lab experiments.