Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation
Our results demonstrated that the 3D bioengineered model proposed here represents a good replica of the native cardiac tissue environment, improving the hiPSC-CMs maturation profile, thus opening the opportunity for its application in disease modeling and toxicological screening studies.
Authors
- Antonella Cecchettini (ORCID: https://orcid.org/0000-0002-2659-026X)
- Elisa Persiani (ORCID: https://orcid.org/0000-0001-6943-8199)
- Claudio Cassino (ORCID: https://orcid.org/0000-0002-7785-2717)
- Silvia Del Ry (ORCID: https://orcid.org/0000-0001-7163-245X)
- Susanna Sartori (ORCID: https://orcid.org/0000-0001-6742-0657)
- Chiara Ippolito (ORCID: https://orcid.org/0000-0001-8671-313X)
- Gianluca Ciardelli
- Letizia Guiducci (ORCID: https://orcid.org/0000-0003-3330-3238)
- Manuela Cabiati (ORCID: https://orcid.org/0000-0002-0811-6257)
- Salvador Fernández‐Arroyo (ORCID: https://orcid.org/0000-0003-0147-1712)
- Rosetta Ragusa (ORCID: https://orcid.org/0000-0002-6914-6089)
- R. Pappalardo (ORCID: https://orcid.org/0000-0002-0650-7801)
- Elisa Ceccherini (ORCID: https://orcid.org/0000-0003-3912-2753)
- Rossella Laurano (ORCID: https://orcid.org/0000-0003-3018-603X)
- Monica Boffito (ORCID: https://orcid.org/0000-0001-7637-2001)
- Federico Vozzi (ORCID: https://orcid.org/0000-0001-5457-2328)
- Ilaria Gisone (ORCID: https://orcid.org/0000-0002-6579-7650)
- Chiara Caselli (ORCID: https://orcid.org/0000-0001-6705-2460)
- Andrea Alliaud
Institutions
- University of Pisa (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Politecnico di Torino (IT)
- Istituto di Fisiologia Clinica (IT)
- Centre for Omic Sciences (ES)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fbioe.2025.1576824
- Citations
- 3
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- European Commission