Immune Dysregulation as a Key Driver of Peripartum Cardiomyopathy – an Exploratory Advanced Imaging and Biomarker Study
Patients with PPCM exhibited a dysregulated immune response, associated with early myocardial interstitial fibrosis and adverse cardiac remodelling. This highlights the importance of rapid initiation of guideline-directed medical therapy especially with drugs documented to have anti-fibrotic effects.
Authors
- Petronella Samuels
- Michael Böhm (ORCID: https://orcid.org/0000-0002-2976-2514)
- Julian Hoevelmann (ORCID: https://orcid.org/0000-0002-2023-3026)
- Lynette Cilliers (ORCID: https://orcid.org/0000-0002-6245-9728)
- Carlos D. Libhaber
- Olivia Briton
- Karen S Sliwa (ORCID: https://orcid.org/0000-0002-8272-0911)
- Morné Kahts
- Ntobeko Ntusi (ORCID: https://orcid.org/0000-0003-2347-7883)
- Fareda Jakoet‐Bassier
- Peter van der Meer
- Denise Hilfiker‐Kleiner (ORCID: https://orcid.org/0000-0001-6065-9649)
- Charle Viljoen (ORCID: https://orcid.org/0000-0001-7246-4136)
- Stephen Jermy (ORCID: https://orcid.org/0000-0001-7045-3863)
- Tessa Kotze
Institutions
- South African Medical Research Council (ZA)
- University Medical Center Groningen (NL)
- University of Cape Town (ZA)
- Philipps University of Marburg (DE)
- University of Groningen (NL)
- University of the Witwatersrand (ZA)
- Groote Schuur Hospital (ZA)
- Medizinische Hochschule Hannover (DE)
- Saarland University (DE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/ejhf.3759
- Citations
- 1
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Research Foundation
- South African Medical Research Council
- Deutsche Forschungsgemeinschaft
- Deutsche Stiftung für Herzforschung
- University of Cape Town
- Medical Research Council