Regioselective C‐9 Arylation of Evodiamine via Bromination and Suzuki Coupling
ABSTRACT A series of 9‐aryl evodiamine derivatives were successfully synthesized in moderate yields via a two‐step, regioselective process involving 9‐bromination with Br 2 followed by Suzuki coupling with various arylboronic acids. The structures of the compounds were confirmed by 1 H NMR, 13 C NMR, and HRMS analysis.
Authors
- Changkuo Zhao (ORCID: https://orcid.org/0000-0001-7973-6333)
- Xianheng Wang
- Yuhe Wang (ORCID: https://orcid.org/0000-0002-9830-5149)
- Hongzhuo Wei
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/jhet.70029
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guizhou Science and Technology Department