Plasma Neurofilament Light Chain and <scp>TNF</scp> ‐α Correlate with Motor Features in Isolated <scp>REM</scp> Sleep Behavior Disorder
We report evidence of peripheral inflammation in early synuclein-related disease processes, and association of plasma NfL and TNF-α with motor dysfunction in iRBD patients, suggesting possible association with increased risk of phenoconversion.
Authors
- Cristina Simonet (ORCID: https://orcid.org/0000-0002-5555-0283)
- Ruth Dobson (ORCID: https://orcid.org/0000-0002-2993-585X)
- Laura Pérez‐Carbonell (ORCID: https://orcid.org/0000-0002-1252-6742)
- Alastair John Noyce (ORCID: https://orcid.org/0000-0003-3027-5497)
- Brook Huxford (ORCID: https://orcid.org/0000-0002-5908-6983)
- Anette E. Schrag (ORCID: https://orcid.org/0000-0002-9872-6680)
- Guy Leschziner (ORCID: https://orcid.org/0000-0001-8799-7226)
Institutions
- Queen Mary University of London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- Royal London Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/mdc3.70210
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- AstraZeneca
- Sanofi
- Biogen
- Celgene
- F. Hoffmann-La Roche
- International Parkinson and Movement Disorder Society
- Barts Charity
- National Institute for Health and Care Research
- University College London
- European Commission
- University College London Hospitals NHS Foundation Trust