Metabolite Profiles of Heart Failure, Central Hemodynamic Derangement, and Response to Heart Transplantation
We comprehensively identified metabolite profiles associated with HF and central hemodynamics that reverse by cardiac transplantation. Increased levels of most metabolites also associated with higher symptom burden. Our findings provide perspectives on the metabolic consequences of HF with potential implications for noninvasive monitoring and tailored therapy.
Authors
- Olof Gidlöf (ORCID: https://orcid.org/0000-0002-7402-3139)
- J. G. Smith (ORCID: https://orcid.org/0000-0001-6285-9935)
- Göran Rådegran
- Charlotta Ljungman (ORCID: https://orcid.org/0000-0002-2785-1919)
- Carl Lejonberg (ORCID: https://orcid.org/0000-0003-1966-5865)
- Jakob Lundgren (ORCID: https://orcid.org/0000-0001-9338-2906)
- Selvi Celik (ORCID: https://orcid.org/0000-0001-7032-3444)
- Anna Egerstedt (ORCID: https://orcid.org/0000-0001-8357-5704)
- Nilanjana Ghosh (ORCID: https://orcid.org/0000-0002-4725-461X)
- Tomasz Czuba (ORCID: https://orcid.org/0009-0001-0232-0425)
Institutions
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Wallenberg Wood Science Center (SE)
- Skåne University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1161/jaha.124.039248
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00