Relationship Between Neutrophil Count and 90‐Day Outcomes and Effect of Dual Antiplatelet Therapy in Patients With Acute Ischemic Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the INSPIRES Trial
The post hoc analysis suggested patients with a higher NC obtained greater benefit from clopidogrel-aspirin than from aspirin without an increase in bleeding risk. The findings may serve as a reference indicator for future anti-inflammatory therapy. However, further research is needed to explore the mechanism.
Authors
- S. Claiborne Johnston (ORCID: https://orcid.org/0000-0002-2912-0714)
- Pierre Amarenco (ORCID: https://orcid.org/0000-0002-3842-1236)
- Y. Wang (ORCID: https://orcid.org/0000-0002-0271-626X)
- Xuan Wang (ORCID: https://orcid.org/0000-0001-5929-6916)
- Xiaoling Liao (ORCID: https://orcid.org/0000-0003-4620-9224)
- Philip M. Bath (ORCID: https://orcid.org/0000-0003-2734-5132)
- Yuesong Pan (ORCID: https://orcid.org/0000-0003-3082-6789)
- Yongjun Wang (ORCID: https://orcid.org/0000-0002-9976-2341)
- Weiqi Chen (ORCID: https://orcid.org/0000-0002-2551-9314)
- Cong Gao (ORCID: https://orcid.org/0000-0001-6798-8381)
- Ying Gao (ORCID: https://orcid.org/0000-0002-7486-6822)
Institutions
- Academy of Medical Sciences (GB)
- Capital University (US)
- University of Nottingham (GB)
- University of California, San Francisco (US)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Population Health Research Institute (CA)
- University of California System (US)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Assistance Publique – Hôpitaux de Paris (FR)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Beijing Academy of Artificial Intelligence (CN)
- Institute of Mental Health (GB)
- National Institute of Neurological Disorders and Stroke (US)
- Chinese Institute for Brain Research (CN)
- Beijing Advanced Sciences and Innovation Center (CN)
- McMaster University (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1161/jaha.124.040492
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71