Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation
The current study indicated that SLNP administration protects against MSG-induced cerebellar damage, preventing cerebellar oxidative stress, inflammation, and apoptosis, opening the door to examining its clinical use in preventing MSG-induced cerebellar motor incoordination.
Authors
- Rehab M. Bagadood (ORCID: https://orcid.org/0000-0001-5873-4152)
- Omer Abdelbagi (ORCID: https://orcid.org/0000-0001-8307-6286)
- Naeem F. Qusty (ORCID: https://orcid.org/0000-0003-4662-6706)
- Medhat Taha (ORCID: https://orcid.org/0000-0001-8440-5002)
- Tourki A. S. Baokbah (ORCID: https://orcid.org/0000-0001-6091-198X)
- Rami J. Obaid
- Ahmed Alzahrani
- Mohammad El-Nablaway
Institutions
- Alfaisal University (SA)
- Mansoura University (EG)
- Umm al-Qura University (SA)
- Almaarefa University
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fmolb.2025.1621240
- Citations
- 3
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 4.56