C3a– <scp>C3aR1</scp> –Mediated Interactions Between Fibroblast–Like Synoviocytes and Macrophages Promote the Progression of Rheumatoid Arthritis
Our study suggests that FLS promotes synovial inflammation via interaction with macrophages through a C3a-C3aR1 signaling-mediated positive feedback regulation. Thus, targeting C3a-C3aR1 signaling might provide a new therapeutic strategy for RA.
Authors
- Haibo Wu (ORCID: https://orcid.org/0000-0003-0817-9191)
- Huizhi Jin
- Minglong Cai (ORCID: https://orcid.org/0000-0002-5038-3703)
- Xi Wen (ORCID: https://orcid.org/0000-0002-7103-9936)
- Zhenyu Li (ORCID: https://orcid.org/0000-0003-2112-9834)
- Yujing Li (ORCID: https://orcid.org/0000-0002-3223-769X)
- Chao Yang (ORCID: https://orcid.org/0000-0002-8661-3275)
- Zhu Chen (ORCID: https://orcid.org/0000-0003-0828-1583)
Institutions
- University of Science and Technology of China (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/art.43319
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 5.00