Microvascular and Blood–Brain Barrier Dysfunction in COL4A1-Related cSVD Can Be Identified by MR DSC Perfusion Imaging
Introduction: Pathogenic variants in COL4A1 compromise basement membrane integrity, leading to cerebral small vessel disease (cSVD) characterized by white matter hyperintensities (WMHs), microbleeds, and ischemic or hemorrhagic strokes [...]
Authors
- John P. Snow (ORCID: https://orcid.org/0000-0002-8569-1431)
- Patricia L. Musolino (ORCID: https://orcid.org/0000-0001-8724-5649)
- Kenda Alhadid (ORCID: https://orcid.org/0000-0001-7582-4862)
- Karl G. Helmer (ORCID: https://orcid.org/0000-0002-5113-6843)
- Arne Lauer (ORCID: https://orcid.org/0000-0001-8906-9706)
- Diana Tambala
- Daniel Balentine
Institutions
- Harvard University (US)
- Heidelberg University (DE)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3390/proceedings2025120009
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts General Hospital