DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases

We identified new DNAm signatures for CVH across diverse cohorts. Our analyses indicate that multiple biological pathways may be relevant to the observed association between CVH and clinical outcomes.

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Publication Details

Journal
Circulation
Published
2025-07-14
DOI
https://doi.org/10.1161/circulationaha.124.073181
Citations
1
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.81
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DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases

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article

DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases

Alexis C. Wood, Amanda M. Fretts, Lifang Hou, Hongyan Ning, Peter Durda, Donald M. Lloyd‐Jones, Kendra Ferrier, Yishu Qu, Kent D. Taylor, Jiantao Ma, María Téllez-Plaza, Hans Jörgen Grabe, Joanne M. Murabito, Matthias Nauck, Jerome I. Rotter, Tom Blackwell, Laura M. Raffield, Yinan Zheng, Marcus Dörr, Wendy S. Post, Russell P. Tracy, Susan Redline, Roby Joehanes, Nancy L. Heard‐Costa, Meng Wang, Vanessa Xanthakis, Dariush Mozaffarian, Stephen S. Rich, Daniel A Levy, Shelley A. Cole, W. Craig Johnson, M. A. Carbonneau, Arce Domingo‐Relloso, Ana Navas‐Acién, Alexander Teumer, April P. Carson, Tianxiao Huan, Yuan‐I Min, Xiuqing Guo, Jie Yao, Brenton Prescott, Chunyu Liu, Jun Wang, Myriam Fornage, Yongmei Liu, Yi Li, Henry Völzke, Mengyao Wang
article en
1 citations

Abstract

We identified new DNAm signatures for CVH across diverse cohorts. Our analyses indicate that multiple biological pathways may be relevant to the observed association between CVH and clinical outcomes.

CirculationVol. 152(7)
Boston University (US), University of Vermont (US), Northwestern University (US), University of North Carolina at Chapel Hill (US), Tufts University (US), Brigham and Women's Hospital (US), Texas Biomedical Research Institute (US), Harvard University (US), Johns Hopkins University (US), Duke University (US), University of Washington (US), University of Michigan (US), Universitätsmedizin Greifswald (DE), Johns Hopkins Medicine (US), Instituto de Salud Carlos III (ES), UCLA Medical Center (US), German Center for Neurodegenerative Diseases (DE), University of Mississippi Medical Center (US), Universität Greifswald (DE), Cancer Research And Biostatistics (US), National Heart, Lung, and Blood Institute (US), Michigan United (US), Anna Needs Neuroblastoma Answers (US), Framingham Heart Study (US), German Centre for Cardiovascular Research (DE), Brown Foundation (US), University of Washington Applied Physics Laboratory (US), Children's Nutrition Research Center at Baylor College of Medicine (US), University of Virginia (US), University of Colorado Anschutz Medical Campus (US), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 26%
Epigenetics and DNA Methylation
0.81
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