DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases
We identified new DNAm signatures for CVH across diverse cohorts. Our analyses indicate that multiple biological pathways may be relevant to the observed association between CVH and clinical outcomes.
Authors
- Alexis C. Wood (ORCID: https://orcid.org/0000-0001-7616-2119)
- Amanda M. Fretts (ORCID: https://orcid.org/0000-0002-5358-2345)
- Lifang Hou (ORCID: https://orcid.org/0000-0003-4877-0031)
- Hongyan Ning (ORCID: https://orcid.org/0000-0003-1157-6614)
- Peter Durda (ORCID: https://orcid.org/0000-0003-4000-2943)
- Donald M. Lloyd‐Jones (ORCID: https://orcid.org/0000-0003-0847-6110)
- Kendra Ferrier (ORCID: https://orcid.org/0000-0002-8813-6871)
- Yishu Qu (ORCID: https://orcid.org/0000-0001-5937-3811)
- Kent D. Taylor (ORCID: https://orcid.org/0000-0002-2756-4370)
- Jiantao Ma (ORCID: https://orcid.org/0000-0001-7478-7203)
- María Téllez-Plaza (ORCID: https://orcid.org/0000-0002-3850-1228)
- Hans Jörgen Grabe (ORCID: https://orcid.org/0000-0003-3684-4208)
- Joanne M. Murabito (ORCID: https://orcid.org/0000-0002-0192-7516)
- Matthias Nauck (ORCID: https://orcid.org/0000-0002-6678-7964)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Tom Blackwell
- Laura M. Raffield (ORCID: https://orcid.org/0000-0002-7892-193X)
- Yinan Zheng (ORCID: https://orcid.org/0000-0002-2006-7320)
- Marcus Dörr (ORCID: https://orcid.org/0000-0001-7471-475X)
- Wendy S. Post (ORCID: https://orcid.org/0000-0002-8655-5204)
- Russell P. Tracy (ORCID: https://orcid.org/0000-0002-0080-2420)
- Susan Redline (ORCID: https://orcid.org/0000-0002-6585-1610)
- Roby Joehanes (ORCID: https://orcid.org/0000-0001-5549-9054)
- Nancy L. Heard‐Costa (ORCID: https://orcid.org/0000-0001-9730-0306)
- Meng Wang (ORCID: https://orcid.org/0000-0001-8345-9180)
- Vanessa Xanthakis (ORCID: https://orcid.org/0000-0002-7352-621X)
- Dariush Mozaffarian (ORCID: https://orcid.org/0000-0001-7958-9492)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- Daniel A Levy (ORCID: https://orcid.org/0000-0003-1843-8724)
- Shelley A. Cole (ORCID: https://orcid.org/0000-0002-2651-0127)
- W. Craig Johnson (ORCID: https://orcid.org/0000-0002-3161-3753)
- M. A. Carbonneau (ORCID: https://orcid.org/0009-0002-4102-5952)
- Arce Domingo‐Relloso (ORCID: https://orcid.org/0000-0001-6928-8290)
- Ana Navas‐Acién (ORCID: https://orcid.org/0000-0001-9824-7797)
- Alexander Teumer (ORCID: https://orcid.org/0000-0002-8309-094X)
- April P. Carson (ORCID: https://orcid.org/0000-0002-7970-6756)
- Tianxiao Huan
- Yuan‐I Min (ORCID: https://orcid.org/0000-0003-2470-0004)
- Xiuqing Guo (ORCID: https://orcid.org/0000-0002-5264-5068)
- Jie Yao (ORCID: https://orcid.org/0000-0002-8822-0651)
- Brenton Prescott (ORCID: https://orcid.org/0000-0002-3805-9070)
- Chunyu Liu (ORCID: https://orcid.org/0000-0002-9160-0153)
- Jun Wang (ORCID: https://orcid.org/0000-0002-2678-2456)
- Myriam Fornage (ORCID: https://orcid.org/0000-0003-0677-8158)
- Yongmei Liu (ORCID: https://orcid.org/0000-0002-6562-1858)
- Yi Li (ORCID: https://orcid.org/0000-0002-5544-750X)
- Henry Völzke
- Mengyao Wang (ORCID: https://orcid.org/0000-0002-6799-8579)
Institutions
- Boston University (US)
- University of Vermont (US)
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Tufts University (US)
- Brigham and Women's Hospital (US)
- Texas Biomedical Research Institute (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Duke University (US)
- University of Washington (US)
- University of Michigan (US)
- Universitätsmedizin Greifswald (DE)
- Johns Hopkins Medicine (US)
- Instituto de Salud Carlos III (ES)
- UCLA Medical Center (US)
- German Center for Neurodegenerative Diseases (DE)
- University of Mississippi Medical Center (US)
- Universität Greifswald (DE)
- Cancer Research And Biostatistics (US)
- National Heart, Lung, and Blood Institute (US)
- Michigan United (US)
- Anna Needs Neuroblastoma Answers (US)
- Framingham Heart Study (US)
- German Centre for Cardiovascular Research (DE)
- Brown Foundation (US)
- University of Washington Applied Physics Laboratory (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
- Columbia University (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1161/circulationaha.124.073181
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81