A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils
We now demonstrate that the bone repair function of monoosteophils requires hydroxyapatite through intracellular nodule formation and monoosteophils are capable of filling in large calvarial defects in our pilot study. These observations may have important implications in facilitating the development of therapeutic applications for clinically challenging bone repairs and the understanding of pathological mineralization.
Authors
- Yuman Fong (ORCID: https://orcid.org/0000-0002-8934-9959)
- John E. Shively (ORCID: https://orcid.org/0000-0002-7763-770X)
- Keith Le
- Chaoxing Zhang (ORCID: https://orcid.org/0000-0003-4115-7111)
- Huinan Liu (ORCID: https://orcid.org/0000-0001-9366-6204)
- Tove Olafsen
- Zhifang Zhang (ORCID: https://orcid.org/0000-0002-1047-2402)
- Zhilin Li (ORCID: https://orcid.org/0000-0002-1636-5376)
Institutions
- University of California, Riverside (US)
- City Of Hope National Medical Center (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fbioe.2025.1583496
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute