Persisting plasma proinsulin levels in a cohort of 482 individuals with long‐standing type 1 diabetes mellitus
In type 1 diabetes mellitus, proinsulin levels remain detectable long after diagnosis, also in the absence of C-peptide, implying the presence of stressed, yet alive β-cells.
Authors
- Richard A. Oram (ORCID: https://orcid.org/0000-0003-3581-8980)
- Elena Rampanelli (ORCID: https://orcid.org/0000-0002-7742-0092)
- Manon Balvers (ORCID: https://orcid.org/0000-0003-4094-5087)
- C. Bruce Verchere (ORCID: https://orcid.org/0000-0002-9262-0586)
- Bart O. Roep (ORCID: https://orcid.org/0000-0002-3110-7391)
- Max Nieuwdorp (ORCID: https://orcid.org/0000-0002-1926-7659)
- Rana Minab (ORCID: https://orcid.org/0000-0002-8679-5339)
- Nordin M.J. Hanssen (ORCID: https://orcid.org/0000-0001-9541-7244)
- Pleun de Groen (ORCID: https://orcid.org/0009-0008-4604-2755)
- Daniël H. van Raalte (ORCID: https://orcid.org/0000-0003-2894-6124)
- Coco M. Fuhri Snethlage (ORCID: https://orcid.org/0009-0009-4166-5045)
- Douwe F. de Wit (ORCID: https://orcid.org/0000-0002-2124-4915)
- Timothy J. McDonald (ORCID: https://orcid.org/0000-0003-3559-6660)
Institutions
- Leiden University (NL)
- Amsterdam Institute for Addiction Research (NL)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- BC Children's Hospital (CA)
- Peninsula College of Medicine and Dentistry (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1111/dom.16604
- Citations
- 1
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Amsterdam University Medical Centers
- Nierstichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Novo Nordisk
- Canadian Institutes of Health Research