Analysis of the Association between SLC30A8 Gene Polymorphism (rs13266634 C/T) and Type 2 Diabetes Mellitus in the North of Jordan

Genetic association studies are beginning to play a role in studying and analysing the risk factors of many complicated metabolic disorders, such as Type 2 Diabetes Mellitus (T2DM). This study appraises the association between the SLC30A8 gene polymorphism (rs13266634 C/T) and T2DM in North Jordan as a potential genetic risk factor for T2DM. The rs13266634 polymorphism was analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The CT genotype was the most prevalent in T2DM (84%) and nondiabetic control groups (91.2%). The TT genotype was observed in only 5.5% of the T2DM group and 4.9% of the nondiabetic group. Allelic analysis disclosed that 49% of the studied population have the T allele, and 51% have the C allele. There were no significant differences in the genotype distribution between the T2DM and the control groups, suggesting that the SLC30A8 gene polymorphism (rs13266634 C/T) is not associated with T2DM in North Jordan and indicating that the SLC30A8 rs13266634 polymorphism is not considered a genetic risk factor for T2DM in the North Jordanian population.