Investigation on Reliability of Administering an Opioid Analgesic Through an Autoinjector by Exploring the Oxidative Stress Parameters in Albino Wistar rats

Modification in drug release provides efficient drug delivery for the benefit of the consumers in improving their convenience, compliance, safety, and efficacy. The need for self-administration of drugs has also evolved due to extreme conditions like natural and man-made disasters to reduce the malaise and fatality. The purpose of this research is to know the reliability of using an opioid analgesic through a self-injectable device during extremity conditions. The opioid analgesic used in this research was buprenorphine. This self-injectable analgesic autoinjector is a recyclable device with the advantage of dose selection. Sterile water from the cartridge was replaced with an opioid analgesic (buprenorphine hydrochloride) under a laminar flow to obtain dosage concentrations of 50μg/mL and 100 μg/mL, respectively. All quality control tests were carried out. Opioid analgesic was given intraperitoneally through an autoinjector in albino rats continuously for 7 or 14 days to evaluate the reliability of using an analgesic autoinjector by observing their oxidative stress parameters. The buprenorphine autoinjector and the drug cartridges quenched the required quality check. There was no sign of bleeding or injury in the essential organs of albino rats in the research categories, when they were autopsied after euthanasia. The oxidative stress parameters, viz., GSH, MDA, SOD, catalase, GPX, and GR of blood and GSH and MDA of liver and kidney showed the absence of any remarkable change in the experimental albino rats. The newly developed analgesic autoinjector was tolerable and reliable in albino rats and renders a scope to extend the research in human participants.