Osteolipomas revisited: a detailed clinical, histologic and molecular characterisation
Our findings support the classification of osteolipomas as conventional lipomas undergoing secondary osseous metaplasia. The identification of HMGA2 fusions, along with their predilection for trauma-prone sites and the observed stromal progression towards bone, suggests a causal association with chronic mechanical stress. Recognising these features is critical to avoid misclassification, particularly as atypical lipomatous tumour/well-differentiated liposarcoma.
Authors
- Rayan Rammal (ORCID: https://orcid.org/0000-0003-1028-3756)
- Ivy John (ORCID: https://orcid.org/0000-0002-4751-7678)
- Shaymaa Hegazy (ORCID: https://orcid.org/0000-0002-1620-2016)
- Azfar Neyaz (ORCID: https://orcid.org/0000-0001-5321-190X)
- Fatma Bilge Ergen (ORCID: https://orcid.org/0000-0002-6368-3959)
- Abigail I. Wald (ORCID: https://orcid.org/0000-0003-0621-5312)
Institutions
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1111/his.15514
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00