Divergent Immune–Metabolic Profiles in Endometriosis and Ovarian Cancer: A Cross-Sectional Analysis
Endometriosis exhibits a distinct immune-metabolic phenotype characterized by M2 macrophage predominance and iron-induced oxidative stress, contrasting with the inflammatory, M1-rich profile of HGS-OC. These findings suggest that iron metabolism and macrophage plasticity contribute to disease persistence in endometriosis and may inform future immunomodulatory strategies.
Authors
- Antonio Macciò (ORCID: https://orcid.org/0000-0003-0577-7217)
- E. Sanna (ORCID: https://orcid.org/0000-0002-6680-5560)
- Paolo Albino Ferrari (ORCID: https://orcid.org/0000-0002-1788-5322)
- Valerio Vallerino (ORCID: https://orcid.org/0000-0002-7933-9757)
- Manuela Neri (ORCID: https://orcid.org/0000-0002-4731-8230)
- Eleonora Lai (ORCID: https://orcid.org/0000-0002-0275-8187)
- Clelia Madeddu (ORCID: https://orcid.org/0000-0001-8940-6987)
Institutions
- University of Cagliari (IT)
- Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari (IT)
- Azienda di Rilievo Nazionale ed Alta Specializzazione (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-07-12
- DOI
- https://doi.org/10.3390/cancers17142325
- Citations
- 4
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.79