Visible‐Light‐Induced Three‐Component Assembly of β‐Hydroxysulfides with Alkenes and Thiosulfonates

Abstract A strategy for the synthesis of β‐hydroxysulfide derivatives via a visible‐light‐induced radical reaction of alkenes with thiosulfonates has been developed. The approach offers a convenient and environmentally friendly route for the simultaneous incorporation of Csp 3 ─O and Csp 3 ─S bonds, affording valuable polyfunctionalized alkane derivatives containing sulfur in satisfactory yields. In addition, the utility of this protocol was manifested by the late‐stage modification of several pharmaceutically relevant molecules, such as flurbiprofen, oxaprozin, febuxostat, and ibuprofen.