Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosis
Our findings illustrate that psychological stress-promoted cancer progression is contributed by the critical liposoluble components LPI (18:0)-mediated FcγR phagocytosis signaling inhibition. GLSO alleviates the dampened phagocytosis of macrophages caused by stress through regulating LPI/FcγR-mediated phagocytosis-related pathways, underscoring its potential as a therapeutic intervention for stress-related tumor progression.
Authors
- Hui Xu (ORCID: https://orcid.org/0000-0001-5517-3556)
- Wan‐Yang Sun (ORCID: https://orcid.org/0000-0002-4439-967X)
- Yangfan Zhou (ORCID: https://orcid.org/0000-0001-5311-1482)
- Yun‐Feng Cao (ORCID: https://orcid.org/0000-0002-6625-5765)
- Wanli Liang
- Yi‐Fang Li (ORCID: https://orcid.org/0000-0002-3356-3702)
- Rong‐Rong He (ORCID: https://orcid.org/0000-0001-5505-5672)
- J. Liu (ORCID: https://orcid.org/0009-0003-5417-3732)
- Guiyuan Xiao (ORCID: https://orcid.org/0000-0002-7163-5017)
- Hongfei Cai (ORCID: https://orcid.org/0000-0002-8083-3816)
- Xiang Luo (ORCID: https://orcid.org/0000-0002-0676-3784)
- Ting Xie (ORCID: https://orcid.org/0000-0002-9958-3888)
- Dongdong Li (ORCID: https://orcid.org/0000-0002-6519-7129)
- Zixuan Li (ORCID: https://orcid.org/0000-0003-2488-814X)
- Ling Jin (ORCID: https://orcid.org/0000-0003-3104-4439)
- Lei Liang (ORCID: https://orcid.org/0009-0000-9700-5809)
- Qijun Chen (ORCID: https://orcid.org/0000-0003-0356-7435)
- Yanping Wu (ORCID: https://orcid.org/0000-0001-8455-3574)
- Wendong Xu
- Yang Liu (ORCID: https://orcid.org/0000-0002-7240-1546)
Institutions
- Macau University of Science and Technology (MO)
- Guangdong Pharmaceutical University (CN)
- University of Macau (MO)
- Ministry of Education (TH)
- Shanghai Institute of Pharmaceutical Industry (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s13020-025-01168-0
- Citations
- 2
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province