Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
The greatest decrease in cognitive impairment was observed among older Chinese adults adhering to both high activity levels and healthy diet, The protective effect was even stronger when high physical activity, high cognitive activity, and a healthy diet were maintained simultaneously, and this trend was consistent regardless of APOEε4 status.
Authors
- Xiaoming Shi (ORCID: https://orcid.org/0000-0002-7071-571X)
- Qiaoqiao Shen (ORCID: https://orcid.org/0000-0002-3491-1684)
- Zhihao Li (ORCID: https://orcid.org/0000-0002-1597-2676)
- Fang‐Fei You
- Wei-Qi Song (ORCID: https://orcid.org/0000-0003-3473-8735)
- Yuebin Lv (ORCID: https://orcid.org/0000-0002-0082-7652)
- Chuan Li (ORCID: https://orcid.org/0000-0001-5147-6699)
- Huan Chen (ORCID: https://orcid.org/0000-0003-4125-0666)
- Chen Mao (ORCID: https://orcid.org/0000-0002-6537-6215)
- Wen-Fang Zhong
- Jian Gao (ORCID: https://orcid.org/0009-0001-9981-093X)
- Xiao-Meng Wang
- Pei‐Liang Chen
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s13195-025-01806-7
- Citations
- 2
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- China Postdoctoral Science Foundation