Testicular Function After Immune‐Checkpoint Inhibitors Treatment
ICI treatment may be associated with minimal spermatogenic dysfunction, as reflected by modest reductions in sperm output and increased serum FSH levels, despite preserved serum LH and testosterone concentrations, but mostly due to a rare (4% prevalence) case of autoimmune orchitis. The unpredictability of these effects supports routine fertility preservation counselling in young men before ICI initiation.
Authors
- David J. Handelsman (ORCID: https://orcid.org/0000-0002-4200-7476)
- Georgina Venetia Long (ORCID: https://orcid.org/0000-0001-8894-3545)
- Sue Sleiman (ORCID: https://orcid.org/0000-0003-4279-9263)
- Andrea Boutros (ORCID: https://orcid.org/0000-0002-5336-5578)
- Feyrous Bacha
- Ting Zhang (ORCID: https://orcid.org/0000-0003-4098-6524)
- Veena Jayadev
- Alexander M. Menzies
- Amanda Idan
Institutions
- The University of Sydney (AU)
- Concord Hospital (US)
- Royal North Shore Hospital (AU)
- Concord Repatriation General Hospital (AU)
- Melanoma Institute Australia (AU)
- Northern Sydney Local Health District (AU)
- Ospedale Policlinico San Martino (IT)
- Anzac Research Institute (AU)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1111/cen.70001
- Citations
- 1
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- University of Sydney
- National Health and Medical Research Council