Yipishen Xiezhuo Jiedu Decoction in Ameliorating Kidney Damage Through miR-223/NLRP3/ Caspase-1 Pathway
This study demonstrates that YPSXZJDD alleviates HN-induced kidney injury by upregulating miR-223 and inhibiting the NLRP3/Caspase-1 pathway. The therapeutic potential of YPSXZJDD is supported by its ability to mitigate inflammation and renal damage, offering a promising approach for HN treatment. Further research into the broader role of miR-223 in kidney disease and related conditions is warranted to expand the understanding of its therapeutic applications.
Authors
- Xiaojing Wu (ORCID: https://orcid.org/0000-0002-8691-1619)
- Qinghui Xu (ORCID: https://orcid.org/0000-0003-3996-3755)
- Weijie Zheng
- Zhangcheng Huang (ORCID: https://orcid.org/0000-0002-2551-7044)
- Huijun Chen (ORCID: https://orcid.org/0000-0003-0293-0917)
- Zi Yu
- Jianfei Weng
- Dengyong Zheng
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Endocrine Metabolic & Immune Disorders - Drug Targets
- Published
- 2025-07-14
- DOI
- https://doi.org/10.2174/0118715303402744250704071034
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00