Plasma Sphingomyelin Levels Mediate the Causal Relationship Between Gut Microbiota and Myocardial Interstitial Fibrosis: A Mendelian Randomization Study
The study validates the causality between particular gut microbial taxa and myocardial interstitial fibrosis, and suggests that plasma sphingomyelin might mediate this association. These findings offer a novel perspective on myocardial interstitial fibrosis prevention, and underscore the significance of plasma sphingomyelin in human health and disease.
Authors
- Jinyu Huang (ORCID: https://orcid.org/0009-0006-4448-4280)
- Xingxiao Huang (ORCID: https://orcid.org/0009-0006-4560-1477)
- Beibei Gao (ORCID: https://orcid.org/0000-0003-0288-0702)
- Mingjun Yu (ORCID: https://orcid.org/0009-0001-0829-1020)
Institutions
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Current Molecular Medicine
- Published
- 2025-07-14
- DOI
- https://doi.org/10.2174/0115665240393776250523073829
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00