Effect of Methylglyoxal on Cell Growth of Saccharomyces Cerevisiae

The accumulation of methylglyoxal causes damage to various eukaryotic organisms, thus resulting in the cell growth and division of eukaryotic organisms. This study demonstrates the physiological role of methylglyoxal in eukaryotic cell. Notably, methylglyoxal is key in detoxification and the regulation of cell division in eukaryotic organisms. Mutant strains of methylglyoxal, i.e., methylglyoxal sensitive B-3 and methylglyoxal resistant MR-2, were derived via ultraviolet irradiation from Saccharomyces cerevisiae. Compared with the case of the parent strain, the specific growth rates of the MR-2 and B-3 strains are approximately 30% higher and 20% lower, respectively.