Antibacterial Activity of Non-Biaryl-Linked Dimeric Tetraxanthones: Insights into Stability and Efficacy against Gram-Positive Bacteria
Aflaxanthone B (<b>1</b>), a non-biaryl-linked dimeric tetraxanthone, was purified from the endophytic fungus <i>Preussia</i> sp. CPCC 401464. Four undescribed transformed products, aflaxanthones C-F (<b>2-5</b>), were obtained by treating compound <b>1</b> with dimethyl sulfoxide (DMSO). Their structures were determined by analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS analyses. The absolute configuration of these compounds was established through X-ray crystallographic analysis and ECD calculations. Only compound <b>1</b> demonstrated significant antibacterial activity against Gram-positive pathogenic bacteria, suggesting a correlation between the stability of compound <b>1</b> and its antibacterial activity.
Authors
- Juxian Wang (ORCID: https://orcid.org/0000-0002-9000-1132)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-3870-4607)
- Xuefu You (ORCID: https://orcid.org/0000-0001-5024-9697)
- Liyan Yu (ORCID: https://orcid.org/0000-0002-8861-9806)
- Wenni He
- Jinglin Bai (ORCID: https://orcid.org/0000-0003-3105-2447)
- Ran Zhang (ORCID: https://orcid.org/0000-0002-6725-6428)
- Guowei Cai
- Xiaomei Fang (ORCID: https://orcid.org/0000-0002-8824-6536)
- Xinxin Hu (ORCID: https://orcid.org/0009-0004-6427-020X)
- Xu Pang
- Hui Lv (ORCID: https://orcid.org/0009-0002-9713-6299)
Institutions
- Binzhou Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- National Drug Addiction Center (BG)
- Institute of Medicinal Plant Development (CN)
- G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (RU)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures (DE)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00624
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00