Manipulating Cell Death in Cancer

Cancer cells often evade regulated cell death to maintain uncontrolled proliferation and withstand therapy. Targeting cell death pathways has emerged as a promising tactic for enhancing anticancer outcomes and overcoming treatment resistance. In addition to highlighting recent developments in therapeutic interventions, this review investigates the molecular mechanisms underlying the various forms of regulated cell deaths in cancer. We discuss small molecule inhibitors and immune-based approaches that take advantage of cell death pathways. Additionally, we address difficulties in clinical translation, such as tumor heterogeneity and off-target effects. This work offers insights into precision therapies that aim to manipulate cell death for better cancer treatment by clarifying the interplay between oncogenic signaling and cell death susceptibility.