Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation
SIRT1 directly binds hepatic PCSK9 and decreases its activity by deacetylation, thereby enhancing LDL-cholesterol clearance by hepatic LDLR upregulation. Boosting circulating SIRT1 exerts atheroprotective effects in mice, with high levels associating with improved prognosis in patients with established ASCVD.
Authors
- Melroy Miranda
- Bart Staels (ORCID: https://orcid.org/0000-0002-3784-1503)
- Priyanka Adla
- Srividya Velagapudi (ORCID: https://orcid.org/0000-0002-7211-4141)
- Ravi Kumar Gutti (ORCID: https://orcid.org/0000-0002-0912-5796)
- T F Luescher (ORCID: https://orcid.org/0000-0002-5259-538X)
- Simon Kraler (ORCID: https://orcid.org/0000-0002-8245-7287)
- Hyo‐Soo Kim (ORCID: https://orcid.org/0000-0003-0847-5329)
- Francesco Paneni (ORCID: https://orcid.org/0000-0001-6483-7844)
- Naresh Babu V. Sepuri (ORCID: https://orcid.org/0000-0001-7077-1255)
- Giovanni G. Camici (ORCID: https://orcid.org/0000-0002-0523-0695)
- Lucia Rohrer (ORCID: https://orcid.org/0000-0002-2167-0818)
- Hyunduk Jang (ORCID: https://orcid.org/0000-0002-7126-3647)
- Alexander Akhmedov (ORCID: https://orcid.org/0000-0003-3052-9493)
- Slayman Obeid (ORCID: https://orcid.org/0000-0002-7672-0923)
- Anne Tailleux (ORCID: https://orcid.org/0000-0003-1430-2627)
- Jérôme Robert (ORCID: https://orcid.org/0000-0002-2847-9362)
- Hwan Lee (ORCID: https://orcid.org/0000-0001-5015-5949)
- S A Mohammed (ORCID: https://orcid.org/0000-0003-2365-5037)
- S. Baki (ORCID: https://orcid.org/0000-0001-8101-4284)
- Arnold von Eckardstein
Institutions
- King's College London (GB)
- Institut Pasteur de Lille (FR)
- Harefield Hospital (GB)
- Seoul National University Hospital (KR)
- University of Hyderabad (IN)
- University Hospital of Zurich (CH)
- Molecular Partners (Switzerland) (CH)
- Biomedical Research Institute (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1093/cvr/cvaf087
- Citations
- 2
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.45
Funders
- National Science Foundation
- Amgen
- Foundation for Cardiovascular Research
- Novartis Foundation
- National Research Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea
- Schweizerische Herzstiftung
- Novartis Stiftung für Medizinisch-Biologische Forschung
- Universität Zürich
- Holcim Stiftung zur Förderung der Wissenschaftlichen Fortbildung