Asymmetric Total Syntheses of (−)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization

Asymmetric total syntheses of (-)-ervatamine and (+)-19,20-dehydroervatamine are described. The key is the directed, late-stage implementation of the indole unit, enabled by the strategically installed ketone group in the central cycloheptene ring.

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Publication Details

Journal
Organic Letters
Published
2025-07-14
DOI
https://doi.org/10.1021/acs.orglett.5c01430
Primary Topic
Alkaloids: synthesis and pharmacology
Type
article
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article

Asymmetric Total Syntheses of (−)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization

Qinyang Chen, Cheon‐Gyu Cho, D. J. JEON
Organic Letters
Alkaloids: synthesis and pharmacology
article

Asymmetric Total Syntheses of (−)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization

Qinyang Chen, Cheon‐Gyu Cho, D. J. JEON
article en

Abstract

Asymmetric total syntheses of (-)-ervatamine and (+)-19,20-dehydroervatamine are described. The key is the directed, late-stage implementation of the indole unit, enabled by the strategically installed ketone group in the central cycloheptene ring.

Organic LettersVol. 27(29)
Hanyang University (KR), Anyang University (KR)
Zero hunger
Openalex Percentile: Top 77%
Alkaloids: synthesis and pharmacology
DOISourceOpenAlex
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Asymmetric Total Syntheses of (−)-Ervatamine and (+)-19,20-Dehydroervatamine via Late-Stage Directed Indolization — Qinyang Chen, Cheon‐Gyu Cho, et al. · Organic Letters (2025) | TGRS Research Map | TGRS