Therapeutic efficacy of a galactoglucan from Pleurotus citrinopileatus in constipation: modulation of aquaporin signaling and intestinal barrier
PCP-g effectively alleviates constipation by enhancing intestinal motility and fecal hydration. It modulates the PKA-AQP3 signaling pathway to improve colonic water permeability and positively influences the gut environment through the generation of SCFAs. These findings suggest that PCP-g may serve as a promising therapeutic candidate for the treatment of constipation, operating through aquaporin signaling and the regulation of the gut environment. The study advocates for further clinical trials and highlights the potential of edible mushroom polysaccharides in the management of constipation.
Authors
- Peiyou Qin (ORCID: https://orcid.org/0000-0002-0351-5646)
- Lan Deng (ORCID: https://orcid.org/0000-0003-0643-7652)
- Dan Wang (ORCID: https://orcid.org/0000-0002-3814-7556)
- Wei Liu (ORCID: https://orcid.org/0000-0003-2940-7755)
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-9873-7902)
- Yi Gao (ORCID: https://orcid.org/0000-0003-0906-4564)
- Xiaoyan Zhao
- Shuang Zhao (ORCID: https://orcid.org/0000-0001-6970-6173)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0002-7133-8485)
Institutions
- Tianjin Agricultural University (CN)
- Institute of Plant Protection (CN)
- Mudanjiang Normal University (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- Beijing Children’s Hospital (CN)
- Beijing Academy of Agricultural and Forestry Sciences (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fnut.2025.1635487
- Primary Topic
- Polysaccharides and Plant Cell Walls
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Academy of Agricultural and Forestry Sciences