Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.)
Hezi dose-dependently induced CYP450 enzyme activity, reversing Zhicaowu's inhibition of CYP1a2/2d2/3a1/2c11 and markedly improving liver function and histopathology. These results elucidate the scientific basis for toxicity reduction in Zhicaowu-Hezi herb pair through metabolic enzyme regulation, supporting its traditional use. Future studies will focus on toxic alkaloid (e.g., aconitine) pharmacokinetics and their transcriptional regulatory pathways.
Authors
- Lanlan Fang (ORCID: https://orcid.org/0000-0001-8725-895X)
- Mengting Chen (ORCID: https://orcid.org/0000-0001-6001-9270)
- Jingjing Guo (ORCID: https://orcid.org/0000-0002-3893-2319)
- Jonathan J. H. Zhu (ORCID: https://orcid.org/0000-0001-6173-6941)
- Ming An (ORCID: https://orcid.org/0000-0002-4264-5996)
- Guodong Wu (ORCID: https://orcid.org/0000-0003-1550-5952)
- Dong Zhang (ORCID: https://orcid.org/0000-0003-0332-1195)
- Weiting Wang (ORCID: https://orcid.org/0000-0001-5840-0902)
- Cen Wang (ORCID: https://orcid.org/0000-0001-6034-4292)
Institutions
- Baotou Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fphar.2025.1573739
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia
- Baotou Medical College