Spontaneous neural activity alterations in medication-naïve primary blepharospasm: a resting-state functional magnetic resonance imaging study

Our findings reveal aberrant spontaneous neural activity within key regions of the motor control network in medication-naïve BSP patients. These ALFF alterations, especially the progressive changes observed in the putamen, provide novel insights into BSP neuropathophysiology and highlight the value of studying untreated cohorts to understand the disorder's intrinsic characteristics.