Shengyu decoction ameliorates knee osteoarthritis by inhibiting endoplasmic reticulum stress via Piezo1 channels
The present results provide strong evidence that SYD protected articular cartilage via inhibiting the Piezo1-mediated ERS signaling pathway. Overall, our work emphasizes the pivotal role of TCM in addressing medical challenges and provides new ideas for the treatment of KOA.
Authors
- Xuyu Song
- Lisong Sheng
- Y P Liu (ORCID: https://orcid.org/0009-0006-8940-0482)
- Xianhui Shen
- Lei Zhang (ORCID: https://orcid.org/0000-0002-5854-2422)
- Si–Yi Chen (ORCID: https://orcid.org/0000-0003-2403-4988)
- Rong Sun (ORCID: https://orcid.org/0000-0003-2356-1495)
- Hongwei Kong (ORCID: https://orcid.org/0000-0002-5841-763X)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Luye Pharma (China) (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fphar.2025.1592818
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shandong University
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China