A stable systemic infection of methicillin-resistant Staphylococcus aureus (MRSA) in cynomolgus macaques produces extended window for therapeutic intervention
In this study, we establish a non-human primate model of systemic MRSA infection that allows for the characterization of MRSA pathogenesis and evaluation of therapeutics over a period of days rather than hours. This model successfully recapitulates key aspects of human MRSA bloodstream infections, providing a valuable platform for evaluating therapeutic interventions and understanding disease mechanisms.
Authors
- Adrienne J Gamblin (ORCID: https://orcid.org/0000-0001-9332-209X)
- Erica Penn
- Jeanne Muench (ORCID: https://orcid.org/0000-0002-1080-5166)
- Karen Feliciano (ORCID: https://orcid.org/0009-0005-6356-0085)
- Gabriella Shumyatsky
- Tatyana Orekov
- Swagata Kar (ORCID: https://orcid.org/0000-0003-3702-6207)
- Samantha J. Simon (ORCID: https://orcid.org/0000-0002-4317-7792)
- Brad Finneyfrock
- Anthony Cook
- Francisco Sánchez de Paz
- M. Peterson
- Grishma Patel (ORCID: https://orcid.org/0009-0003-9579-2687)
- Darnell Bushby
- Amanda Womer
- Helal Kabir
Institutions
- Bioqual (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1601381
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.40