IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection
These findings highlight the role of IDO-mediated TRP catabolism and innate immune signaling in promoting a tolerogenic phenotype during <i>P. vivax</i> infection. The study provides novel insights into mechanisms that may contribute to immune regulation, chronic inflammation, and tolerance during malaria, with potential implications for therapeutic interventions.
Authors
- Marcus Lacerda (ORCID: https://orcid.org/0000-0003-3374-9985)
- Adolfo José da Mota (ORCID: https://orcid.org/0000-0002-9745-1128)
- Fernanda Fortes de Araújo (ORCID: https://orcid.org/0000-0002-8066-3677)
- Stefanie Costa Pinto Lopes (ORCID: https://orcid.org/0000-0002-6981-2192)
- Adriana Malheiros
- Thiago Barros do Nascimento de Morais (ORCID: https://orcid.org/0000-0002-3174-1288)
- Andréa Teixeira‐Carvalho (ORCID: https://orcid.org/0000-0003-2814-5183)
- Paulo Afonso Nogueira (ORCID: https://orcid.org/0000-0001-9677-7225)
- Pritesh Lalwani (ORCID: https://orcid.org/0000-0003-2996-0446)
- Elaine Speziali de Faria
- Rafaella Oliveira dos Santos (ORCID: https://orcid.org/0000-0003-4446-9663)
- Maria Geuziane Soares da Cruz
- Helton C. Santiago (ORCID: https://orcid.org/0000-0002-5695-8256)
- Nani Oliveira Carvalho (ORCID: https://orcid.org/0000-0002-5859-728X)
- Wlademir Braga Salgado Sobrinho
- Vanessa Peruhype-Magalhães (ORCID: https://orcid.org/0000-0002-2907-2724)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais (BR)
- Instituto Nacional de Pesquisas da Amazônia (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1474447
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Amazonas