Acute degradation of nucleolin reveals its novel functions in cell cycle progression and cell division in triple negative breast cancer
Our findings indicate a novel role for NCL in supporting the completion of the cell division in TNBC models, and that its abrogation could enhance the therapeutic activity of mitotic-progression inhibitors.
Authors
- Thomas J. Magliery (ORCID: https://orcid.org/0000-0003-0779-1477)
- Anna Tessari (ORCID: https://orcid.org/0000-0002-6036-1954)
- Ashley B. Reers
- Wayne Miles (ORCID: https://orcid.org/0000-0002-2054-5206)
- Ilaria Cosentini (ORCID: https://orcid.org/0000-0002-0214-3537)
- Vollter Anastas (ORCID: https://orcid.org/0000-0001-5078-2838)
- Emanuele Cocucci (ORCID: https://orcid.org/0000-0002-0088-9845)
- Joseph Mills
- Vincenzo Coppola (ORCID: https://orcid.org/0000-0001-6163-1779)
- Lara Rizzotto (ORCID: https://orcid.org/0000-0002-2658-9103)
- Heather R. Shive (ORCID: https://orcid.org/0000-0001-9148-2591)
- Alexander E. Davies (ORCID: https://orcid.org/0000-0002-1917-8816)
- Dario Palmieri (ORCID: https://orcid.org/0000-0002-0797-4268)
- Carlo Maria Croce (ORCID: https://orcid.org/0000-0003-3788-1457)
- Damu Sunilkumar (ORCID: https://orcid.org/0000-0003-0376-6039)
- Zirui Zhu (ORCID: https://orcid.org/0000-0003-4008-6518)
- Nastaran Samadi Rad
- Saranya Lamba
Institutions
- Tulane University (US)
- Tufts University (US)
- Oregon Health & Science University (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- The Ohio State University Wexner Medical Center (US)
- Radiation Oncology Institute (US)
- Institute for Biomedical Research and Innovation (IT)
- National Cancer Institute (US)
- Department of Health and Human Services (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s13046-025-03401-y
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ohio State University
- National Institutes of Health
- Office of Research Infrastructure Programs, National Institutes of Health