Acute degradation of nucleolin reveals its novel functions in cell cycle progression and cell division in triple negative breast cancer

Our findings indicate a novel role for NCL in supporting the completion of the cell division in TNBC models, and that its abrogation could enhance the therapeutic activity of mitotic-progression inhibitors.

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Publication Details

Journal
Journal of Experimental & Clinical Cancer Research
Published
2025-07-14
DOI
https://doi.org/10.1186/s13046-025-03401-y
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

Acute degradation of nucleolin reveals its novel functions in cell cycle progression and cell division in triple negative breast cancer

Thomas J. Magliery, Anna Tessari, Ashley B. Reers, Wayne Miles et al.
Journal of Experimental & Clinical Cancer Research
RNA modifications and cancer
article

Acute degradation of nucleolin reveals its novel functions in cell cycle progression and cell division in triple negative breast cancer

Thomas J. Magliery, Anna Tessari, Ashley B. Reers, Wayne Miles, Ilaria Cosentini, Vollter Anastas, Emanuele Cocucci, Joseph Mills, Vincenzo Coppola, Lara Rizzotto, Heather R. Shive, Alexander E. Davies, Dario Palmieri, Carlo Maria Croce, Damu Sunilkumar, Zirui Zhu, Nastaran Samadi Rad, Saranya Lamba
article en

Abstract

Our findings indicate a novel role for NCL in supporting the completion of the cell division in TNBC models, and that its abrogation could enhance the therapeutic activity of mitotic-progression inhibitors.

Journal of Experimental & Clinical Cancer ResearchVol. 44(1)
Tulane University (US), Tufts University (US), Oregon Health & Science University (US), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), The Ohio State University Wexner Medical Center (US), Radiation Oncology Institute (US), Institute for Biomedical Research and Innovation (IT), National Cancer Institute (US), Department of Health and Human Services (US), The Ohio State University (US)
Ohio State University, National Institutes of Health, Office of Research Infrastructure Programs, National Institutes of Health
Good health and well-being
Openalex Percentile: Top 85%
RNA modifications and cancer
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