m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy
This study revealed the presence of m5C modifications on circRREB1 and showed that m5C-modified circRREB1 can induce mitophagy, ultimately promoting lung cancer. These findings provide not only a theoretical basis for further exploration of the mechanisms underlying lung cancer development but also potential targets for lung cancer therapy.
Authors
- Aruo Nan (ORCID: https://orcid.org/0000-0003-0351-8561)
- Xiaodong Zhou (ORCID: https://orcid.org/0000-0001-8198-5902)
- Wenyi Peng (ORCID: https://orcid.org/0000-0001-7699-6850)
- Deqing Li
- Haotian Xu (ORCID: https://orcid.org/0000-0003-1673-6779)
- Yihong Gao (ORCID: https://orcid.org/0000-0002-9293-4075)
- Xingcai Chen (ORCID: https://orcid.org/0000-0002-9489-5014)
- Gang Li (ORCID: https://orcid.org/0000-0003-3184-1032)
- Ruirui Zhang (ORCID: https://orcid.org/0000-0003-1898-1487)
- Jiaxi Wu
- Qingyun Zhao
- Shengyi Yuan
- Dunyu Cai
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s13046-025-03460-1
- Citations
- 6
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China