PILs of Knowledge: A Synthetic Benchmark for Evaluating Question Answering Systems in Healthcare

Patient Information Leaflets (PILs) provide essential information about medication usage, side effects, precautions, and interactions, making them a valuable resource for Question Answering (QA) systems in healthcare. However, no dedicated benchmark currently exists to evaluate QA systems specifically on PILs, limiting progress in this domain. To address this gap, we introduce a fact-supported synthetic benchmark composed of multiple-choice questions and answers generated from real PILs. We construct the benchmark using a fully automated pipeline that leverages multiple Large Language Models (LLMs) to generate diverse, realistic, and contextually relevant question-answer pairs. The benchmark is publicly released as a standardized evaluation framework for assessing the ability of LLMs to process and reason over PIL content. To validate its effectiveness, we conduct an initial evaluation with state-of-the-art LLMs, showing that the benchmark presents a realistic and challenging task, making it a valuable resource for advancing QA research in the healthcare domain.

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Publication Details

Published
2025-07-13
DOI
https://doi.org/10.1145/3726302.3730283
Citations
2
Primary Topic
Topic Modeling
Type
article
Field-Weighted Citation Impact
4.96

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article

PILs of Knowledge: A Synthetic Benchmark for Evaluating Question Answering Systems in Healthcare

Stefano Mizzaro, Michael Soprano, Paolo Coppola, Vincenzo Della Mea et al.
2 citations
Topic Modeling
4.96
article

PILs of Knowledge: A Synthetic Benchmark for Evaluating Question Answering Systems in Healthcare

Stefano Mizzaro, Michael Soprano, Paolo Coppola, Vincenzo Della Mea, Kevin Roitero, Riccardo Lunardi
article en
2 citations

Abstract

Patient Information Leaflets (PILs) provide essential information about medication usage, side effects, precautions, and interactions, making them a valuable resource for Question Answering (QA) systems in healthcare. However, no dedicated benchmark currently exists to evaluate QA systems specifically on PILs, limiting progress in this domain. To address this gap, we introduce a fact-supported synthetic benchmark composed of multiple-choice questions and answers generated from real PILs. We construct the benchmark using a fully automated pipeline that leverages multiple Large Language Models (LLMs) to generate diverse, realistic, and contextually relevant question-answer pairs. The benchmark is publicly released as a standardized evaluation framework for assessing the ability of LLMs to process and reason over PIL content. To validate its effectiveness, we conduct an initial evaluation with state-of-the-art LLMs, showing that the benchmark presents a realistic and challenging task, making it a valuable resource for advancing QA research in the healthcare domain.

University of Udine (IT)
Università degli Studi di Udine, Regione Autonoma Friuli Venezia Giulia, European Social Fund
Openalex Percentile: Top 5%
Topic Modeling
4.96
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PILs of Knowledge: A Synthetic Benchmark for Evaluating Question Answering Systems in Healthcare — Stefano Mizzaro, Michael Soprano, et al. · (2025) | TGRS Research Map | TGRS