Efficacy and Cost-Effectiveness of MDM2 Fluorescence In Situ Hybridization (FISH) in Morphologically Atypical Spermatic Cord Lipomas

Our results indicate that 2.3% of morphologically atypical specimens labeled as spermatic cord lipoma at our institution are in fact well-differentiated liposarcomas. These findings prove the efficacy of <i>MDM2</i> FISH in diagnosing WDLS in the setting of atypical spermatic cord lipoma labeled specimens. Although 97.7% of our spermatic cord lipomas harbored reactive-type atypia with negative FISH results, which argues against the cost-effectiveness of such testing, we propose performing FISH analysis in cases greater than 10 cm in size to avoid misdiagnosis and ensure optimal patient care.