TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D <sub>3</sub> metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway
TsR-0072 acted as an anti-oncogene to modulate lipid and vitamin D<sub>3</sub> metabolic reprogramming, thereby impeding CRC progression. Consequently, it might be a potential therapeutic target to overcome metabolic disorders in tumours. This study provided a promising transfer RNA (tRNA)-oriented strategy for the treatment of CRC treatment.
Authors
- Hongyi Bao
- Qianyi Qi
- Jing Xu (ORCID: https://orcid.org/0000-0003-4864-1870)
- Bairong Chen
- Guang Zhu (ORCID: https://orcid.org/0000-0001-9970-4988)
- Feng Wang (ORCID: https://orcid.org/0000-0002-4721-1062)
- Lin Chen (ORCID: https://orcid.org/0000-0002-6453-7996)
- Kangfeng Jin
- Jinran Wu
Institutions
- Nantong University (CN)
- Hong Kong University of Science and Technology (HK)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-07-13
- DOI
- https://doi.org/10.1080/07853890.2025.2531253
- Citations
- 2
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China