An exploratory analysis of 5‐alpha reductase inhibitors and risk of opioid use disorder among male Medicare beneficiaries receiving prescription opioid medications
This first of its kind in humans study suggests that concomitant use of opioids and 5αRI is associated with a reduction in OUD and maybe a preventive therapy for patients at risk of OUD. Our findings align with animal models that have shown similar findings.
Authors
- Ainhoa Gómez-Lumbreras (ORCID: https://orcid.org/0000-0002-3916-0402)
- Marco Bortolato (ORCID: https://orcid.org/0000-0002-4498-9637)
- Randall T. Peterson (ORCID: https://orcid.org/0000-0003-0727-3469)
- Daniel C. Malone (ORCID: https://orcid.org/0000-0002-5006-9394)
- T. Andrew Lister
- Abdelrahman Tawfik (ORCID: https://orcid.org/0000-0003-0914-7669)
Institutions
- American Association of Colleges of Pharmacy (US)
- University of Utah (US)
- Florida College (US)
Publication Details
- Journal
- American Journal on Addictions
- Published
- 2025-07-13
- DOI
- https://doi.org/10.1111/ajad.70069
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00