Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats
Arabinoxylan improved depressive-like behavior in rats and its neuroprotective role was achieved by promoting the growth of intestinal probiotics, improving the intestinal barrier, affecting the BDNF/TrkB/p-CREB signaling pathway, and increasing the expression levels of monoamine neurotransmitters 5-HT, DA and NE.
Authors
- Ling Huang (ORCID: https://orcid.org/0000-0002-4007-5766)
- Jun Zhou (ORCID: https://orcid.org/0009-0003-5358-5735)
- Binyu Bi
- Lin Lin (ORCID: https://orcid.org/0000-0003-4702-7190)
- Jie Wang (ORCID: https://orcid.org/0000-0002-5602-0487)
- Xuebin Li (ORCID: https://orcid.org/0000-0002-5898-4570)
- W. B. Yan (ORCID: https://orcid.org/0000-0002-0210-9734)
- Liu Huang (ORCID: https://orcid.org/0000-0003-4469-6145)
Institutions
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-07-13
- DOI
- https://doi.org/10.1186/s12868-025-00964-6
- Citations
- 3
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 3.49