miR-144-3p targeting FLRT3 in osteogenic differentiation of mandibular bone marrow mesenchymal stem cells
miR-144-3p regulates the osteogenic differentiation of MBMSCs by targeting and modulating FLRT3, with FLRT3 being a direct target of miR-144-3p. During osteogenic differentiation, miR-144-3p inhibits osteogenesis by downregulating FLRT3, BMP2, and RUNX2 expression. This study not only elucidates the miRNA-mediated regulatory mechanism in osteogenesis but also offers a novel strategy for mandibular bone defect repair.
Authors
- Kang Yin (ORCID: https://orcid.org/0000-0002-0532-5475)
- Jingjun Tian
- Chaofeng Liu (ORCID: https://orcid.org/0000-0003-2942-1418)
- Changyu Liu (ORCID: https://orcid.org/0009-0006-6161-207X)
- Qi Sun (ORCID: https://orcid.org/0000-0001-8605-1578)
- Wen Ma (ORCID: https://orcid.org/0009-0004-9510-7579)
- Lv Chen (ORCID: https://orcid.org/0000-0001-5488-0427)
- Tao Xie
- Yanhua Xu
- Renyi Cheng
Institutions
- Kunming Medical University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-07-13
- DOI
- https://doi.org/10.1186/s40246-025-00788-9
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China