Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation
Taken together, our data suggest that humanization of the reaction specificity of mouse Alox15 (Leu353Phe mutation) exhibits differential effects in two mouse inflammation models.
Authors
- Halina Machelska (ORCID: https://orcid.org/0000-0001-6315-2958)
- Sabine Stehling
- Gerhard P. Püschel (ORCID: https://orcid.org/0000-0002-0943-7060)
- Michael Rothe (ORCID: https://orcid.org/0000-0002-4243-4582)
- Florian Reisch
- Hartmut Kühn (ORCID: https://orcid.org/0000-0001-8142-3192)
- Dagmar Heydeck (ORCID: https://orcid.org/0000-0002-1394-6925)
- Dominika Łabuz (ORCID: https://orcid.org/0000-0003-2465-4730)
- Marjann Schäfer
Institutions
- University of Potsdam (DE)
- Humboldt-Universität zu Berlin (DE)
- Lipidomix (Germany) (DE)
- German Institute of Human Nutrition (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-07-13
- DOI
- https://doi.org/10.1186/s11658-025-00756-0
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Charité – Universitätsmedizin Berlin