Clonal hematopoiesis of indeterminate potential and risk of incident Crohn’s disease—a prospective cohort study
CHIP was associated with a markedly increased risk of subsequent CD. The association was particularly stronger in JAK2-mutant CHIP, ASXL1-mutant CHIP, and DNMT3A-mutant CHIP. The findings of this study may offer potential insights for future investigations into the mechanistic underpinnings of CD.
Authors
- Ola Olén (ORCID: https://orcid.org/0000-0002-5478-7019)
- Qifa Liu (ORCID: https://orcid.org/0000-0003-4015-3952)
- Asa Hallqvist Everhov (ORCID: https://orcid.org/0000-0002-0311-8894)
- Qianwei Liu (ORCID: https://orcid.org/0000-0002-4687-100X)
- Huiwen Xue (ORCID: https://orcid.org/0009-0009-8422-8275)
- Yuqing Wang (ORCID: https://orcid.org/0000-0002-2169-8626)
- Hui Wei (ORCID: https://orcid.org/0000-0003-2568-9345)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Karolinska Institutet (SE)
- Guangdong Province Stomatological Hospital (CN)
- Stockholm South General Hospital (SE)
- Sachs' Children and Youth Hospital (SE)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf118
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00