Features of circulating in the blood desquamated endotheliocytes at the patients with hypertonic disease accompanied by alcoholism

Introduction and aim. Previously, we found the characteristics of desquamated endothelial cells circulating in the blood (CECs) in patients with diabetic angiopathy as well as stage II hypertension accompanied by ischemic heart disease. The literature on the effects of alcohol consumption on the cardiovascular system is mixed. Therefore, the aim of this study was to determine the characteristics of CECs in patients with hypertonic disease accompanied by alcoholism. Material and methods. The object of clinical observation was 38 patients of both sexes with stage II hypertension, which in 20 of them was accompanied by chronic alcoholism. The control group consisted of 21 healthy volunteers. The main subject of the study was the levels of blood pressure and CECs. In addition, routine general blood analysis performed and determined metabolic parameters in serum. Results. It was found that alcoholism is accompanied by minimal for the sample subnormal levels of markedly and terminally altered circulating endothelial cells (ACEC), LDLP cholesterol, triglycerides, prothrombin, Klimov’s and Dobiasova’s&Frolich’s atherogenity indices, ankle-brachial index of blood pressure (as atherogenity marker) as well as glucose, platelets and leukocytes. Instead, such patients have the maximum for the sample levels of HDLP cholesterol, erythrocytes sedimentation rate, body mass index, urea and creatinine. At the same time, the levels of hemoglobin, erythrocytes and cholesterol total as well as negentropy of endotheliocytogram and lipidogram did not differ from the controls, despite the presence of AH II. At the same time, both diastolic and systolic hypertension are less pronounced than in sober patients. Canonical correlation analysis showed that the absolute levels of the three fractions of CECs are determined by a constellation of 11 factors by 66,7%. Instead, the percentage and negetropy of CECs correlate with the registered factors much weaker (R2=0,390). The U-shape relationship between duration of alcohol consumption and number body parameters detected. Conclusion. Alcohol consumption by patients with arterial hypertension has a significant impact on a number of body parameters, the severity of which depends nonlinearly on the duration of alcoholism.