Exploring Schiff base bromhexine derivatives: study on synthesis, characterization, biological assays, molecular docking
Molecular docking studies against α-amylase and α-glucosidase revealed strong inhibition scores, with BM6 and BM7 emerging as the most promising candidates. This study concludes that derivatives could serve as lead compounds in the development of novel therapeutic agents.
Authors
- M. A. Bhat (ORCID: https://orcid.org/0000-0001-8426-4692)
- Mohamed A. Al‐Omar (ORCID: https://orcid.org/0000-0002-9866-343X)
- Breena Awan (ORCID: https://orcid.org/0000-0003-1100-9062)
- Farhat Ullah (ORCID: https://orcid.org/0000-0001-7907-0842)
- Anum Masood (ORCID: https://orcid.org/0000-0002-9879-9038)
- Javed Ahmed
- Mohsin Abbas Khan (ORCID: https://orcid.org/0000-0002-3178-5467)
- Muhammad Toseef Akram (ORCID: https://orcid.org/0009-0006-2043-2937)
- Asim Raza (ORCID: https://orcid.org/0000-0001-6059-7804)
- Saharish Khaliq (ORCID: https://orcid.org/0000-0002-0908-9721)
- Zarmeena Yasmeen (ORCID: https://orcid.org/0000-0003-4395-291X)
Institutions
- Islamia University of Bahawalpur (PK)
- Mehran University of Engineering and Technology (PK)
- King's College London (GB)
- Islamia College University (PK)
- King Saud University (SA)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1080/17568919.2025.2527619
- Citations
- 1
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- King Saud University