How macrophages use extracellular calreticulin to chase their prey
Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity.
Authors
- Oliver Kepp (ORCID: https://orcid.org/0000-0002-6081-9558)
- Guido Kroemer (ORCID: https://orcid.org/0000-0002-9334-4405)
- Liwei Zhao (ORCID: https://orcid.org/0000-0001-5077-327X)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1682-9222)
Institutions
- Institut Gustave Roussy (FR)
- La Ligue Contre le Cancer (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
Publication Details
- Journal
- OncoImmunology
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1080/2162402x.2025.2533494
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Association pour la Recherche sur le Cancer
- Seerave Foundation
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Cancéropôle Ile de France
- Fondation Gustave Roussy
- HORIZON EUROPE European Innovation Council