Development and Evaluation of a Bifunctional Metronidazole and Bmp-2 Controlled Release Scaffold for Periodontal Regeneration

Periodontitis is a common inflammatory periodontal disease characterized by the destruction of bone tissue and requires an integrated treatment approach. In this study, an intelligent scaffold based on a collagen-hyaluronic matrix was developed that provides pH-dependent metronidazole release and prolonged delivery of recombinant bone morphogenetic protein-2 (rhBMP-2). Scaffold demonstrated pronounced antimicrobial activity against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomita