Bionic Janus Fiber Enabling Autonomous Exudate Management and Multimodal Sterilization for Diabetic Wounds

Diabetic wound healing remains a persistent clinical challenge where exudate management and targeted disinfection constitute critical therapeutic priorities. Drawing inspiration from nature's asymmetric wettability in Janus-structured lotus leaves, we engineered a biomimetic wound dressing system that synergistically integrates directional biofluid transport and photothermal/photodynamic sterilization. The hierarchically structured PP/PAN-<i>x</i>Cu-TCPP fiber dressing combines a hydrophobic polypropylene (PP) substrate with an electrospun polyacrylonitrile (PAN) nanofibrous matrix incorporating copper-porphyrin metal-organic frameworks (Cu-TCPP MOFs). This Janus architecture orchestrates unidirectional fluid dynamics <i>via</i> surface tension and contact angle differentials from the hydrophobic to the hydrophilic layer, effectively preventing exudate accumulation while maintaining physiologically moist microenvironments. The PP/PAN-20%Cu-TCPP fiber dressing confers spatiotemporal therapeutic control under near-infrared (NIR) irradiation, generating reactive oxygen species (ROS) and photothermal bactericidal effects. In <i>Staphylococcus aureus</i>-infected diabetic mice models, the dual-laser activated PP/PAN-20%Cu-TCPP system demonstrates excellent microbial eradication, immunomodulation by suppressing hyperinflammation and directing macrophage polarization toward regenerative M2 phenotypes, and angiogenic potentiation <i>via</i> dual phototherapeutic activation of endothelial cells and stromal remodeling. This multifunctional paradigm effectively bridges the critical gap between infection control and pro-regenerative microenvironment establishment, thereby accelerating wound repair.